I might have to give another run through with Renegade actually. I want to see how the last decision regarding whether to destroy or salvage the Collector base comes back on you. But since I'm pretty sure Cerberus is your enemy in ME3, it's probably best you destroy it. Haven't read any spoilers or anything, but I've seen Cerberus logos on the heavy mechs you fight in some of the previews. And I don't think it's any coincidence that Martin Sheen's eyes looked an awful lot like Saren's. I don't want to know any more than that though.