I'll do my quick top 10 predictions that can happen but some may be a stretch.
1. CM Punk has a lengthy reign till at least Mania. Probably Over The Limit have him drop it (Extreme Rules is in his hometown). Let him drop it to Ziggler or Miz (would prefer Ziggler) but one of those heels would be great.
2. Drew McIntyre becomes relevant again and I mean by actually winning matches. I'm happy that he's finally being noticed but something needs to happen with him.
3. Dolph Ziggler and Wade Barrett will break out for the main championships on the respective brands. They are the best young stars right now (sorry Rhodes) and deserve to be main figures on the brand.
4. Speaking of Rhodes, I do think he should be a main event guy but I need to see him in more feuds. Barrett and Ziggler have big time experience in long feuds while Rhodes doesn't have many memorable feuds. In the pecking order, Rhodes is below the other two. A nice few big feuds and Rhodes will be a huge hit.
5. Curt Hawkins finally becomes relevant too and wins the tag team championship with Tyler Reks. Reks is pretty talented even though his mic work is pretty weak. Hawkins has impressive talent and needs some time to show it on the main shows.
6. RVD finally returns and gets some nice feuds, possibly even feuding with Rhodes in the future.
7. Randy Orton will get his Wrestlemania moment by beating Daniel Bryan. Orton never had his moment yet of winning the title at Mania and he will do that against Bryan. Then the IWC will blow up.
8. Ted DiBiase will win a singles title. I'm not big on his gimmick and still find him stale, but it's clear that he's starting to get over and will get a mid card title at some point.
9. Kofi Kingston will turn heel. 2011 was the year of the great heel turns like Henry and R-Truth. Kofi needs a character switch desperately because he'll be a face for over 3 years soon. They need to give him a chance because he has the charisma to do it. People may be pessimistic but then again most people thought that R-Truth wouldn't do well as a heel. Then he became an amazing heel and was praised.
10. The last one will be that Smackdown finally goes to Tuesday. That seems like a long shot, but i have faith.