He doesn't seem to care. You can tell a person that they're gay on COD (insult intended), and they'll react the same exact way. It's a troll tactic, really.
Ryback doesn't realize that CM Punk is actually insulting him.
He knows. He just knows that agreeing with Punk will make him even more mad because he can't retaliate. He worked with Punk don't forget. Everyone knows he is a snob.