I still wouldn't consider a match with Rey Mysterio (that could end up being Mysterio's retirement match) at Wrestlemania XXX out of the question.
He could also either get himself a partner (Mysterio after he breaks away from Big Show, that is if Mysterio manages to stay injury free for that long, which he won't) and add another good tag team to the ever-growing division and/or compete for the Intercontinental and United States Championships (more likely the latter) somewhere down the line.