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Nah there's only one Thursday game so if none of your players are in it you can leave it alone until Sunday morning, you just set a starting lineup of your best players each week so most will obviously play on Sundays but there's the one Thursday and Monday game too
But like if someone is injured and their team is playing on Thursday then you can't take them out once the game starts so you'll have a player put up a 0 for that position which would hurt you
But basically you have x amount of starters and x amount of bench players and you only get points for how your starters do so you just need to make sure you have who you think will do the best in your starting lineup and you can't change if anyone is in your lineup once their game starts