I don't know that they WILL, but yah, they easily could.
Kane has been put through the wringer in terms of ridiculous storylines that made him look stupid (and in the case of Katie Vick, that even contradicted his entire backstory as a gimmick) but he still gathered up enough momentum to win the WHC in 2010. But as mentioned, Kane doesn't want to win world championships. He's claimed that he's been offered them in real life but turned most of them down because he'd rather put over young(er) talent than have to shoulder the responsibility of carrying the company in some regards.
I doubt Daniel Bryan will ever win the WWE Title (which everyone knows is king in terms of the world titles) but I'm pretty certain he'll win the WHC again. I can even imagine him cutting a promo (as a face) on how he wants to erase that bad memory of losing the belt in 18 seconds and wants to have a more successful title reign this next time around. I still don't see him ever being a major player in the main event (well, WHC isn't really 'main event' but whatever) in the long run. As PSachkovsky said, he fits perfectly as well in the IC and US title pictures.