I'm predicting Show/Orton leads to Show/HHH, which then leads to Show/Kane at Wrestlemania.
Many think Kane will cost Show the championship against Orton, leading to Big Show running through Kane and then finally getting his hands on Triple H. But then once that's over, where does Big Show go from there? Show/HHH is obviously not being saved for Mania, and since Kane will still be aligned with the Authority by then and Show still in conflict with them, saving Show/Kane for Wrestlemania gives them both something to do there. Kane costs Show the match against HHH, which then leads to Show/Kane and also Bryan/HHH for Mania, with HHH getting heat and making himself look superior by going over Show.
An alternate idea I had is Big Show winning the title from Orton and then dropping it to Triple H, which leads to Bryan winning the Rumble and then challenging and defeating HHH for the belt at Mania (and Show/Kane can still happen at Mania in this scenario.)