Spoiler for Mass Effect two, guys, but seriously if you aint played the game by now....
In my first playthrough, you know in 2010, I upgraded the Normandy and lost some of the NPC characters such as the Irish guy in engineering. Now on my PC playthrough I do everyone's loyalty mission, and upgrade the Normandy, but call Mordin out on his genophage dealings. This time I saved all the NPC people, but Mordin got killed. Does someone have to die in the battle against the Collectors? It just seems like a forgone conclusion that either an NPC or a main character is going to die...