Show won't interfere in the actual match. The cell's placement around the ring is to keep people out and Big Show has no reason to help either Bryan (who can handle Orton on his own) or Orton (whom he hates) to win.
What I see happening, and the closet we'll get to 'interference' in the match, is The Shield running out at the end when Orton is in a crucial spot (a bad one) to try and break into the cell with bolt cutters. But then Cody, Goldust and probably Ziggler come out and start brawling with them (I see that six man tag match being booked for HIAC) and Big Show then arrives out of nowhere and helps to outnumber The Shield in a big way and helps put all three of them down. I quite like the image of all this carnage going on on the outside while Bryan and Orton still go at it inside the cell. And then Bryan puts Orton down and wins the WWE Title. The show ends with Michaels/Show/Cody/Goldust/Ziggler (i.e all the main people who have been in this fight with Bryan against the HHH authority the past couple of months, plus the guy who trained him) all in the ring celebrating Bryan's title win by lifting him on their shoulders while he raises the belt in the air and the whole arena chants Yes (that'll be the big image on wwe.com.) PPV ends with HHH and Stephanie fuming at the entrance way.
If they do a 5-on-5 elimination match for Survivor Series, there's your possible babyface team - Bryan, Ziggler, Rhodes, Goldust, Show.