I think they'll do at least one more match between him and Del Rio at Summerslam just to get the most mileage out of that feud as possible. Possibly a special stipulation the third time around. It's possible they have Del Rio DQ himself at MITB and only have him drop the belt come Summerslam. I'd have no issue with this personally, as I'd rather have Ziggler chase the title that's in the clutches of a heel Del Rio for two months rather than one. It builds a little more anticipation towards Ziggler finally recapturing the gold.
After that, maybe they'll go ahead with the split between Ziggler and AJ/Big E Langston. Something drives a wedge between Ziggler and AJ, and as a result of Ziggler dumping her (maybe she interferes and accidentally costs him the match at MITB or Summerslam or at least comes close to doing so), she sics Big E Langston on him and Langston promises to take his WHC from him. I picture him laying Ziggler out at some point and holding up his belt and saying that he'll never see this again as long as it's in his grasp. I like the image of him stealing the belt and coming out on the next show with it on his shoulder while AJ simultaneously holds up the Diva's title. Ziggler defeating Langston and thus getting his 'victory' over the both of them seems like a good idea on how to split him apart from them for good.