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I don't even know what demographic Kutcher appeals to. let alone know why the guy was famous to begin with.
Spin City aside, I don't recall other shows survivng long after a main character is replaced with another.
Would make no difference to me, I didn't like the show when Sheen was on it, I won't be watching Kutcher on it either. When a sitcom has a laugh track, it's a sign that it isn't a good show.