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Having someone replace Charlie Sheen in that role would be a big mistake. The best idea would be to write out Charlies character and then bring in a new character to replace him.
I have read names like John Stamos and Rob Lowe as possible replacements on the show. The show is a massive ratings...
This was bound to happen after the comment Sheen made about the creator of the show. Tough decision though because this will cost them hundreds of millions of dollars. I can't see the show working without Charlie Sheen but there hasn't been any word on if they will cancel the show or not.